Part of Clavicular's Looksmaxxing Stack

TB-500 is the systemic recovery peptide in Clavicular's looksmaxxing stack. The Wolverine duo with BPC-157.

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Product Specifications

Active Sequence:: Ac-LKKTETQ (core actin-binding motif)
Full Name:: Thymosin Beta-4 fragment (synthetic analogue)
Molecular Weight:: 2174.5 Da
Form:: Lyophilized powder
Purity:: ≥98% (HPLC verified)
Storage:: −20°C long-term / 4°C up to 4 weeks reconstituted
Reconstitution:: Bacteriostatic water

TB-500 (Thymosin Beta-4) 10mg

Name: TB-500 (Thymosin Beta-4) 10mg
Brand: Phiogen
SKU: PG-1008
Price: 59.99 USD
Availability: InStock
Rating: 4.9 (214 reviews)

Featured in Clavicular's looksmaxxing protocol

Synthetic Thymosin Beta-4 fragment — researched for actin regulation, satellite cell activation, and systemic tissue repair. The most studied systemic repair peptide available alongside BPC-157.

$59.99In Stock

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Why Clavicular Uses This Peptide

TB-500 is the systemic recovery peptide in Clavicular's looksmaxxing stack. The Wolverine duo with BPC-157.

See Clavicular's complete looksmaxxing stack →

Actin Sequestration & Satellite Cell Activation

TB-500 is a synthetic analogue of the active Ac-LKKTETQ region of Thymosin Beta-4 (Tβ4), a 43-amino-acid peptide present in virtually all nucleated cells. Its primary mechanism is G-actin sequestration via the Ac-LKKTETQ motif — this promotes cell migration, angiogenesis, and tissue repair by controlling actin polymerization dynamics. TB-500 activates satellite cells (muscle stem cells), upregulates metalloproteinases for ECM remodeling, and reduces pro-inflammatory cytokines including TNF-α and IL-1β. Its systemic cell migration properties make it complementary to BPC-157's local angiogenic mechanism — the two are the most studied peptide repair combination in published literature. Multiple animal model studies demonstrate accelerated healing across skeletal muscle, tendon, cardiac tissue, and peripheral nerves. Molecular weight: 2174.5 Da.

Why Buy TB-500 (Thymosin Beta-4) 10mg

Satellite Cell Activation

TB-500 promotes satellite cell (muscle stem cell) entry into the cell cycle and differentiation into myoblasts. In vitro and animal models demonstrate increased satellite cell proliferation at injury sites, driving muscle regeneration after damage. This makes TB-500 particularly relevant to skeletal muscle repair, atrophy recovery, and exercise-induced damage research.

Cardiac & Vascular Research

Multiple studies have examined Thymosin Beta-4 in cardiac repair post-infarction. Animal models demonstrate reduced cardiomyocyte apoptosis, improved neovascularization, and enhanced functional recovery after ischemic injury. TB-500's VEGF upregulation and endothelial cell migration promotion are the primary vascular mechanisms.

Synergy with BPC-157

TB-500 and BPC-157 are the most studied peptide combination in healing research. BPC-157 drives local angiogenesis and growth factor upregulation at injury sites; TB-500 drives systemic cell migration and actin regulation. The complementary pathways make the combination the standard benchmark in regenerative peptide research.

Frequently Asked Questions

What is the difference between TB-500 and BPC-157?

TB-500 (Thymosin Beta-4 fragment) primarily acts via actin sequestration and satellite cell activation — most relevant to muscle and connective tissue repair. BPC-157 acts via VEGFR2, FAK-paxillin, and nitric oxide pathways with a broader tissue profile including GI cytoprotection. They are frequently studied in combination for synergistic healing effects.

How does TB-500 differ from native Thymosin Beta-4?

TB-500 is a synthetic fragment corresponding to the Ac-LKKTETQ core actin-binding region of the 43-amino-acid Thymosin Beta-4 peptide. It retains the primary biological activity of the parent peptide at a lower molecular weight, with comparable results in published research.

How should TB-500 be reconstituted?

Add 1–2mL bacteriostatic water to a 10mg vial. At 1mL: 10mg/mL. At 2mL: 5mg/mL. Store reconstituted at 4°C, use within 4 weeks. Gently swirl — do not shake.

Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.